Maturation of the infant rhesus macaque gut microbiome and its role in the development of diarrheal disease.

ABSTRACT:

Background

Diarrhea is the second leading cause of death in children under 5 years of age. Enhanced understanding of causal pathways, pathogenesis, and sequelae of diarrhea is urgently needed. Although the gut microbiota is believed to play a role in susceptibility to diarrheal diseases, our understanding of this association remains incomplete. Infant rhesus macaques (Macaca mulatta) are susceptible to diarrhea making them an ideal model to address this question.

Results

The maturation of the infant rhesus macaque gut microbiome throughout the first 8 months of life occurs in a similar pattern as that described for human infants. Moreover, the microbiome of the captive reared infant rhesus macaque more closely resembles that of human infants in the developing world than in t

SUBMITTER: Rhoades N 

PROVIDER: S-EPMC6709555 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature