Evaluation of pharmacokinetic modeling strategies for in-vivo quantification of tau with the radiotracer [¹⁸F]MK6240 in human subjects.

ABSTRACT:

Purpose

[¹⁸F]MK6240 was developed for PET imaging of tau aggregates, which are implicated in Alzheimer's disease. The goal of this work was to evaluate the kinetics of [¹⁸F]MK6240 and to investigate different strategies for in-vivo quantification of tau aggregates in humans.

Methods

Thirty-five subjects, consisting of 18 healthy controls (CTRL), 11 subjects with mild cognitive impairment (MCI) and six with Alzheimer's Disease (AD), underwent dynamic [¹⁸F]MK6240 PET scans. Arterial blood measurements were collected in 16 subjects (eight CTRLs, six MCIs and two AD) to measure whole blood and plasma concentration time courses. Radiometabolite analysis was performed on a subset of plasma samples. Various compartmental model configurations as well

SUBMITTER: Guehl NJ 

PROVIDER: S-EPMC6709592 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature