Platelet packing density is an independent regulator of the hemostatic response to injury.

ABSTRACT: Essentials Platelet packing density in a hemostatic plug limits molecular movement to diffusion. A diffusion-dependent steep thrombin gradient forms radiating outwards from the injury site. Clot retraction affects the steepness of the gradient by increasing platelet packing density. Together, these effects promote hemostatic plug core formation and inhibit unnecessary growth.

Summary

Background Hemostasis studies performed in vivo have shown that hemostatic plugs formed after penetrating injuries are characterized by a core of highly activated, densely packed platelets near the injury site, covered by a shell of less activated and loosely packed platelets. Thrombin production occurs near the injury site, further activating platelets and starting the process of platelet mass retracti

SUBMITTER: Mirramezani M 

PROVIDER: S-EPMC6709675 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature