Integration of curated and high-throughput screening data to elucidate environmental influences on disease pathways.

ABSTRACT: Addressing the complex relationship between public health and environmental exposure requires multiple types and sources of data. An important source of chemical data derives from high-throughput screening (HTS) efforts, such as the Tox21/ToxCast program, which aim to identify chemical hazard using primarily in vitro assays to probe toxicity. While most of these assays target specific genes, assessing the disease-relevance of these assays remains challenging. Integration with additional data sets may help to resolve these questions by providing broader context for individual assay results. The Comparative Toxicogenomics Database (CTD), a publicly available database that builds networks of chemical, gene, and disease information from manually curated literature sources, offers a prom

SUBMITTER: Kosnik MB 

PROVIDER: S-EPMC6709694 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature