Alzheimer's Disease Susceptibility Genes in Malignant Breast Tumors.

ABSTRACT:

Background

Cognitive problems have been reported in breast cancer patients after chemotherapy. A small group of older breast cancer survivors carrying the APOE4 gene, receiving chemotherapy, was at increased risk of long-term impairment of brain function. We have analyzed the expression of APOE and the next 23-ranked Alzheimer's disease (AD) susceptibility genes in malignant breast tumors. We wished to determine if these 24 genes might be related to breast cancer.

Methods

To identify the most important AD susceptibility genes, we consulted the ALZGENE database (www.alzgene.org/) which displays this information and regularly updates it. To analyze the effect of AD susceptibility genes on breast cancer, we used The Cancer Genome Atlas (TCGA). We analyzed TCGA data with cBioPor

SUBMITTER: Lehrer S 

PROVIDER: S-EPMC6709700 | biostudies-literature | 2019 Apr-Jun

REPOSITORIES: biostudies-literature