Genetic variants in a sodium-dependent vitamin C transporter gene and age-related cataract.

ABSTRACT:

Background

Cataract is a major health burden in many countries and a significant problem in India. While observational studies show lower cataract risk with increasing dietary or plasma vitamin C, randomised controlled trials of supplements have been negative. Genetic variants in vitamin C transporter proteins (SLC23A1), especially rs33972313, may provide evidence on a causal association of vitamin C with cataract.

Methods

We used data from a randomly selected population-based study in people aged 60 years and above in north and south India. Of 7518 sampled, 5428 (72%) were interviewed for socioeconomic and lifestyle factors, attended hospital for lens imaging and blood collection and were subsequently genotyped for rs33972313 and rs6596473. Mixed or pure types of cat

SUBMITTER: Ravindran RD 

PROVIDER: S-EPMC6709767 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature