The relationship between the reporting of euphoria events and early treatment responses to pregabalin: an exploratory post-hoc analysis.

ABSTRACT:

Background

Euphoria is a complex, multifactorial problem that is reported as an adverse event in clinical trials of analgesics including pregabalin. The relationship between the reporting of euphoria events and pregabalin early treatment responses was examined in this exploratory post-hoc analysis.

Methods

Data were from patients with neuropathic or non-neuropathic chronic pain enrolled in 40 randomized clinical trials, who received pregabalin (75-600 mg/day) or placebo. Reports of treatment-emergent euphoria events were based on the Medical Dictionary of Regulatory Activities preferred term "euphoric mood". Prevalence rates of euphoria events overall and by indication were assessed. Post-treatment endpoints included ≥30% improvements in pain and sleep scores up to 3 weeks a

SUBMITTER: Parsons B 

PROVIDER: S-EPMC6709807 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature