Glutamate receptor interacting protein acts within the prefrontal cortex to blunt cocaine seeking.

ABSTRACT: Glutamate receptor interacting protein (GRIP) is a neuronal scaffolding protein that anchors GluA2-containing AMPA receptors to the cell membrane. GRIP plays a critical role in activity-dependent synaptic plasticity, including that which occurs after drug exposure. Given that cocaine administration alters glutamate receptor trafficking within the prefrontal cortex (PFC), a better understanding of the role of receptor trafficking proteins could lead to a more complete understanding of addictive phenotypes. AMPA receptor trafficking in general, and GRIP specifically, is known to play a role in cocaine seeking and conditioned reward in the nucleus accumbens, but its role in the PFC has not been characterized. The current study demonstrates that conditional deletion of GRIP1 in the medial pref

SUBMITTER: Wickens MM 

PROVIDER: S-EPMC6709847 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature