No evidence for higher rates of hepatocellular carcinoma after direct-acting antiviral treatment: a meta-analysis.

ABSTRACT:

Aim

Hepatitis C virus (HCV) is the leading cause of hepatocellular carcinoma (HCC) in the United States. Achieving sustained viral response with interferon (IFN) treatment reduces the risk from 3%-5% to 0.5%-1% annually. Several studies reported unexpectedly high rates of HCC after treatment with direct-acting antivirals (DAAs). The aim of our study was to compare HCC rates in DAA-, IFN-treated and untreated populations.

Methods

A literature search was conducted using ScienceDirect, Ovid®, Web of Science and MEDLINE through January 2019. Studies were included if they measured rates of de novo or recurrent HCC (following curative treatment) in HCV-infected persons. We included 138 studies (n = 177,512). Simple pooling of data and meta-analysis were performed, us

SUBMITTER: Rutledge SM 

PROVIDER: S-EPMC6709867 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature