A RID-like putative cytosine methyltransferase homologue controls sexual development in the fungus Podospora anserina.

ABSTRACT: DNA methyltransferases are ubiquitous enzymes conserved in bacteria, plants and opisthokonta. These enzymes, which methylate cytosines, are involved in numerous biological processes, notably development. In mammals and higher plants, methylation patterns established and maintained by the cytosine DNA methyltransferases (DMTs) are essential to zygotic development. In fungi, some members of an extensively conserved fungal-specific DNA methyltransferase class are both mediators of the Repeat Induced Point mutation (RIP) genome defense system and key players of sexual reproduction. Yet, no DNA methyltransferase activity of these purified RID (RIP deficient) proteins could be detected in vitro. These observations led us to explore how RID-like DNA methyltransferase encoding genes would play a r

SUBMITTER: Grognet P 

PROVIDER: S-EPMC6709928 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature