The role of functional status on the relationship between blood pressure and cognitive decline: the Cardiovascular Health Study.

ABSTRACT:

Objective

To examine whether self-reported functional status modified the association between blood pressure (BP) and cognitive decline among older adults.

Methods

The study included 2097 US adults aged 75 years and older from the Cardiovascular Health Study, followed for up to 6 years. Functional status was ascertained by self-reported limitation in activities of daily living (ADL; none vs. any). Cognitive function was assessed by the Modified Mini Mental State Exam (3MSE). We used linear mixed models to examine whether the presence of at least one ADL limitation modified the association between BP and cognitive decline. Potential confounders included demographics, physiologic measures, antihypertensive medication use and apolipoprotein E ε4 allele. We conducted stratified

SUBMITTER: Miller LM 

PROVIDER: S-EPMC6709980 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature