Expansion of Luminal Progenitor Cells in the Aging Mouse and Human Prostate.

ABSTRACT: Aging is associated with loss of tissue mass and a decline in adult stem cell function in many tissues. In contrast, aging in the prostate is associated with growth-related diseases including benign prostatic hyperplasia (BPH). Surprisingly, the effects of aging on prostate epithelial cells have not been established. Here we find that organoid-forming progenitor activity of mouse prostate basal and luminal cells is maintained with age. This is caused by an age-related expansion of progenitor-like luminal cells that share features with human prostate luminal progenitor cells. The increase in luminal progenitor cells may contribute to greater risk for growth-related disease in the aging prostate. Importantly, we demonstrate expansion of human luminal progenitor cells in BPH. In summary, we d

SUBMITTER: Crowell PD 

PROVIDER: S-EPMC6710009 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature