Environmental exposure to polybrominated biphenyl (PBB) associates with an increased rate of biological aging.

ABSTRACT: Advanced age increases risk for cancer, cardiovascular disease, and all-cause mortality. However, people do not age at the same rate, and biological age (frequently measured through DNA methylation) can be older than chronological age. Environmental factors have been associated with the rate of biological aging, but it is not known whether persistent endocrine-disrupting compounds (EDCs) like polybrominated biphenyl (PBB) would associate with age acceleration. Three different epigenetic age acceleration measures (intrinsic, extrinsic, and phenotypic) were calculated from existing epigenetic data in whole blood from a population highly exposed to PBB (N=658). Association between serum PBB concentration and these measures was tested, controlling for sex, lipid levels, and estimated cell type

SUBMITTER: Curtis SW 

PROVIDER: S-EPMC6710070 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature