Bone regeneration strategies: Engineered scaffolds, bioactive molecules and stem cells current stage and future perspectives.

ABSTRACT: Bone fractures are the most common traumatic injuries in humans. The repair of bone fractures is a regenerative process that recapitulates many of the biological events of embryonic skeletal development. Most of the time it leads to successful healing and the recovery of the damaged bone. Unfortunately, about 5-10% of fractures will lead to delayed healing or non-union, more so in the case of co-morbidities such as diabetes. In this article, we review the different strategies to heal bone defects using synthetic bone graft substitutes, biologically active substances and stem cells. The majority of currently available reviews focus on strategies that are still at the early stages of development and use mostly in vitro experiments with cell lines or stem cells. Here, we focus on what is alre

SUBMITTER: Ho-Shui-Ling A 

PROVIDER: S-EPMC6710094 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature