Unstable wakefulness during resting-state fMRI and its associations with network connectivity and affective psychopathology in young adults.

ABSTRACT:

Background

Drifts between wakefulness and sleep are common during resting state functional MRI (rsfMRI). Among healthy adults, within-scanner sleep can impact functional connectivity of default mode (DMN), task-positive (TPN), and thalamo-cortical networks. Because dysfunctional arousal states (i.e., sleepiness, sleep disturbance) are common in affective disorders, individuals with affective psychopathology may be more prone to unstable wakefulness during rsfMRI, hampering the estimation of clinically meaningful functional connectivity biomarkers.

Methods

A transdiagnostic sample of 150 young adults (68 psychologically distressed; 82 psychiatrically healthy) completed rsfMRI and reported whether they experienced within-scanner sleep. Symptom scales were reduced into depressi

SUBMITTER: Soehner AM 

PROVIDER: S-EPMC6710159 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature