Structural neuroimaging differentiates vulnerability from disease manifestation in colombian families with Huntington's disease.

ABSTRACT:

Introduction

The volume of the striatal structures has been associated with disease progression in individuals with Huntington's disease (HD) from North America, Europe, and Australia. However, it is not known whether the gray matter (GM) volume in the striatum is also sensitive in differentiating vulnerability from disease manifestation in HD families from a South-American region known to have high incidence of the disease. In addition, the association of enlarged brain perivascular spaces (PVS) with cognitive, behavioral, and motor symptoms of HD is unknown.

Materials and methods

We have analyzed neuroimaging indicators of global atrophy, PVS burden, and GM tissue volume in the basal ganglia and thalami, in relation to behavioral, motor, and cognitive scores, in 15 HD pati

SUBMITTER: Valdes Hernandez MDC 

PROVIDER: S-EPMC6710228 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature