Estimating the cold-induced brown adipose tissue glucose uptake rate measured by ¹⁸F-FDG PET using infrared thermography and water-fat separated MRI.

ABSTRACT: Brown adipose tissue (BAT) expends chemical energy to produce heat, which makes it a potential therapeutic target for combating metabolic dysfunction and overweight/obesity by increasing its metabolic activity. The most well-established method for measuring BAT metabolic activity is glucose uptake rate (GUR) measured using ¹⁸F-fluorodeoxyglucose (FDG) positron emission tomography (PET). However, this is expensive and exposes the subjects to potentially harmful radiation. Cheaper and safer methods are warranted for large-scale or longitudinal studies. Potential alternatives include infrared thermography (IRT) and magnetic resonance imaging (MRI). The aim of this study was to evaluate and further develop these techniques. Twelve healthy adult subjects were studied. The BAT GUR was

SUBMITTER: Andersson J 

PROVIDER: S-EPMC6710246 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature