Molecular profiling of tissue biopsies reveals unique signatures associated with streptococcal necrotizing soft tissue infections.

ABSTRACT: Necrotizing soft tissue infections (NSTIs) are devastating infections caused by either a single pathogen, predominantly Streptococcus pyogenes, or by multiple bacterial species. A better understanding of the pathogenic mechanisms underlying these different NSTI types could facilitate faster diagnostic and more effective therapeutic strategies. Here, we integrate microbial community profiling with host and pathogen(s) transcriptional analysis in patient biopsies to dissect the pathophysiology of streptococcal and polymicrobial NSTIs. We observe that the pathogenicity of polymicrobial communities is mediated by synergistic interactions between community members, fueling a cycle of bacterial colonization and inflammatory tissue destruction. In S. pyogenes NSTIs, expression of specialized viru

SUBMITTER: Thanert R 

PROVIDER: S-EPMC6710258 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature