The impact of liver transplant recipient and donor genetic variability on tacrolimus exposure and transplant outcome.

ABSTRACT: This study investigated the effect of recipient and donor genetic variability on dose-adjusted steady-state tacrolimus concentrations (C_ss ) and clinical outcomes 3 and 6 months after liver transplant. Twenty-nine recipients and matched donor blood samples were genotyped for 27 single nucleotide polymorphisms including CYP3A5*3 (rs776746), ABCB1 haplotype and immune genes. Associations between genetic variability and clinical parameters and C_ss and the occurrence of rejection and nephrotoxicity were analysed by multivariate and multinomial logistic regression modelling and Jonckheere-Terpstra tests examined the impact of combined donor/recipient CYP3A5 expression on C_ss . At 3 months post-transplant modelling revealed an association between tacrolimus C

SUBMITTER: Coller JK 

PROVIDER: S-EPMC6710513 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature