BRCA mutation in high grade epithelial ovarian cancers.

ABSTRACT:

Objective

To identify the frequency of BRCA mutation in patients with high grade epithelial ovarian cancer (EOC).

Methods

Patients with EOC included fallopian tube cancer or peritoneal cancer with high grade serous or high grade endometrioid were recruited. BRCA1 and BRCA2 mutations were tested and analyzed by next generation sequencing system.

Results

A total of 87 patients were recruited; majority of them (88.5%) were EOC, 5.7% fallopian tube cancer, 4.6% peritoneal cancer, and 1.1% synchronous primary ovarian and endometrial cancer. Seventy-four patients (85.1%) had high grade serous carcinoma and 13 patients (14.9%) had high grade endometrioid carcinoma. Germline BRCA mutation was detected in 19 patients (21.8%); 14 patients (16.1%) had

SUBMITTER: Manchana T 

PROVIDER: S-EPMC6710551 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature