A gelatin hydrogel to study endometrial angiogenesis and trophoblast invasion.

ABSTRACT: The endometrium is the lining of the uterus and site of blastocyst implantation. Each menstrual cycle, the endometrium cycles through rapid phases of growth, remodelling and breakdown. Significant vascular remodelling is also driven by trophoblast cells that form the outer layer of the blastocyst. Trophoblast invasion and remodelling enhance blood flow to the embryo ahead of placentation. Understanding the mechanisms of endometrial vascular remodelling and trophoblast invasion would provide key insights into endometrial physiology and cellular interactions critical for establishment of pregnancy. The objective of this study was to develop a tissue engineering platform to investigate the processes of endometrial angiogenesis and trophoblast invasion in a three-dimensional environment. We re

SUBMITTER: Zambuto SG 

PROVIDER: S-EPMC6710659 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature