Associations between TAB2 Gene Polymorphisms and Epithelial Ovarian Cancer in a Chinese Population.

ABSTRACT:

Background

Epithelial ovarian cancer (EOC) is highly lethal worldwide. Factors involved in the inflammation and hormone-associated signaling pathway play vital roles in EOC carcinogenesis. The transforming growth factor-β- (TGF-β-) activated kinase 1 (MAP3K7) binding protein 2 (TAB2), mediating convergence of inflammatory and estrogen, may be implicated in EOC. The present study is aimed at exploring the association between the TAB2 gene polymorphisms and EOC.

Methods

Three single nucleotide polymorphisms (SNPs) (rs237028, rs521845, and rs652921) of TAB2 were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 221 patients and 252 healthy controls. Associations between SNPs and clinical characterist

SUBMITTER: Huang X 

PROVIDER: S-EPMC6710735 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature