Evolution of the CYP51 gene in Mycosphaerella graminicola: evidence for intragenic recombination and selective replacement.

ABSTRACT: Recent findings are consistent with a slow but constant shift towards reduced sensitivity of Mycosphaerella graminicola to azole fungicides, which target the CYP51 gene. The goal of this study was to elucidate the evolutionary mechanisms through which CYP51-based mutations associated with altered sensitivity have evolved in M. graminicola over space and time. To accomplish this, we sequenced and compared a portion of the CYP51 gene encompassing the main mutations associated with altered sensitivity towards demethylation inhibitor fungicides. The CYP51 gene showed an extraordinary dynamic shift consistent with a selective haplotype replacement both in space and in time. No mutations associated with increased resistance to azoles were found in non-European populations. These mutations were a

SUBMITTER: Brunner PC 

PROVIDER: S-EPMC6710900 | biostudies-literature | 2008 May

REPOSITORIES: biostudies-literature