Temporal association of the development of oropharyngeal microbiota with early life wheeze in a population-based birth cohort.

ABSTRACT:

Background

A critical window in infancy has been proposed, during which the microbiota may affect subsequent health. The longitudinal development of the oropharyngeal microbiota is under-studied and may be associated with early-life wheeze. We aimed to investigate the temporal association of the development of the oropharyngeal microbiota with early-life wheeze.

Methods

A population-based birth cohort based in London, UK was followed for 24 months. We collected oropharyngeal swabs at six time-points. Microbiota was determined using sequencing of the V3-V5 region of the 16S rRNA-encoding gene. Medical records were reviewed for the outcome of doctor diagnosed wheeze. We used a time-varying model to investigate the temporal association between the development of microbiota and

SUBMITTER: Powell EA 

PROVIDER: S-EPMC6710983 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature