The cellular prion protein controls the mesenchymal-like molecular subtype and predicts disease outcome in colorectal cancer.

ABSTRACT:

Background

Comprehensive transcriptomic analyses have shown that colorectal cancer (CRC) is heterogeneous and have led to the definition of molecular subtypes among which the stem-cell, mesenchymal-like group is associated with poor prognosis. The molecular pathways orchestrating the emergence of this subtype are incompletely understood. In line with the contribution of the cellular prion protein PrP^C to stemness, we hypothesize that deregulation of this protein could lead to a stem-cell, mesenchymal-like phenotype in CRC.

Methods

We assessed the distribution of the PrP^C-encoding PRNP mRNA in two large CRC cohorts according to molecular classification and its association with patient survival. We developed cell-based assays to explore the impact of gain

SUBMITTER: Le Corre D 

PROVIDER: S-EPMC6710984 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature