Cognitive and Physical Function by Statin Exposure in Elderly Individuals Following Acute Myocardial Infarction.

ABSTRACT: Despite beneficial effects on morbidity and mortality after acute myocardial infarction (AMI), concerns remain about the safety of statin therapy, particularly their potential effects on cognitive and physical function, in elderly individuals. Among statin-naive AMI patients age ≥ 65 years in a multicenter US registry, we examined the association between statin prescription at discharge and change in cognition (via Modified Telephone Interview for Cognitive Status [TICS-M]) assessed at 1 and 6 months after AMI. Short Form-12 Physical Component score, hand grip, walk time, and chair-rise tests were used to assess physical function. We conducted noninferiority testing to evaluate the hypothesis that the mean change in cognitive function was no worse among patients recently started on statins

SUBMITTER: Swiger KJ 

PROVIDER: S-EPMC6710994 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature