Beneficial Effects of Positive Airway Pressure Therapy for Sleep-Disordered Breathing in Heart Failure Patients With Preserved Left Ventricular Ejection Fraction.

ABSTRACT:

Background

Right-heart dysfunction is associated with poor prognosis in heart failure with preserved left ventricular ejection fraction (HFpEF). It remains unclear whether sleep-disordered breathing (SDB) treatment using positive airway pressure (PAP) improves right-heart and pulmonary function and exercise capacity and reduces mortality rates of HFpEF patients.

Hypothesis

PAP may improve right-heart and pulmonary function, exercise capacity and prognosis in HFpEF patients with SDB.

Methods

One hundred nine consecutive patients with HFpEF (left ventricular ejection fraction >50%) and moderate to severe SDB (apnea-hypopnea index ≥15/h) treated with medications were divided into 2 groups: 31 patients with PAP (PAP group) and 78 patients without PAP (non-PAP group). Righ

SUBMITTER: Yoshihisa A 

PROVIDER: S-EPMC6710995 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature