Human bone marrow adipocytes display distinct immune regulatory properties.

ABSTRACT:

Background

The bone marrow (BM) is a major reservoir of resting memory T cells and long-lived plasma cells, capable of providing protection against recurrent infections. Whether the age-related accumulation of adipose tissue in the BM affects the functionality and maintenance of memory cells is not well understood.

Methods

For the first time, we compare human femur marrow adipose tissue (fMAT) and subcutaneous white adipose tissue of the thigh (tsWAT) obtained from the same donors. Therefore, we used microarrays for comparative global gene expression analysis, and employed assays to analyse parameters of adipocyte biology, inflammation and oxidative stress.

Findings

We show that fMAT adipocytes differ significantly from tsWAT adipocytes regarding specific gene express

SUBMITTER: Miggitsch C 

PROVIDER: S-EPMC6711052 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature