Corticosteroids significantly increase cystatin C levels in the plasma by promoting cystatin C production in rats.

ABSTRACT: Background: Several studies have shown that non-renal factors such as corticosteroids may increase plasma cystatin C levels without affecting kidney function. However, the mechanisms underlying this are unclear. We hypothesized that corticosteroids may increase cystatin C levels in the plasma by promoting its production in tissues. In the present study, we aimed to test our hypothesis in rats by investigating the effect of corticosteroids on cystatin C production in tissues and the glomerular filtration rate (GFR), as measured by the gold standard method (i.e., inulin clearance). Results: Dexamethasone treatment was associated with much higher concentrations of cystatin C in all organ tissue homogenates tested. Dexamethasone increased plasma cystatin C levels in rats, without

SUBMITTER: Zhu XR 

PROVIDER: S-EPMC6711078 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature