Transcriptome analyses suggest minimal effects of Shank3 dosage on directional gene expression changes in the mouse striatum.

ABSTRACT: Both deletions and duplications of the SH3 and multiple ankyrin repeat domains 3 (SHANK3) gene, encoding excitatory postsynaptic scaffolds, are causally associated with various brain disorders, suggesting that proper Shank3 dosage is critical for normal brain development and function. In addition to its well-established synaptic functions, recent studies have suggested that Shank3 can also affect gene expression in the nucleus. However, it has not been investigated whether there are a group of genes whose directional expression is regulated in a Shank3 dosage-dependent manner (i.e. showing opposite changes in expression following Shank3 reduction and overexpression). This is an important issue to be examined for better understanding why neuronal development and function are sensitive to Sh

SUBMITTER: Lee Y 

PROVIDER: S-EPMC6711111 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature