Quantitative proteomics reveals reduction of endocytic machinery components in gliomas.

ABSTRACT:

Background

Gliomas are the most frequent and aggressive malignancies of the central nervous system. Decades of molecular analyses have demonstrated that gliomas accumulate genetic alterations that culminate in enhanced activity of receptor tyrosine kinases and downstream mediators. While the genetic alterations, like gene amplification or loss, have been well characterized, little information exists about changes in the proteome of gliomas of different grades.

Methods

We performed unbiased quantitative proteomics of human glioma biopsies by mass spectrometry followed by bioinformatic analysis.

Findings

Various pathways were found to be up- or downregulated. In particular, endocytosis as pathway was affected by a vast and concomitant reduction of multiple machinery com

SUBMITTER: Buser DP 

PROVIDER: S-EPMC6711119 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature