The African strain of Zika virus causes more severe in utero infection than Asian strain in a porcine fetal transmission model.

ABSTRACT: Studies in mice showed that African Zika virus (ZIKV) strains cause more damage in embryos. These studies, however, were limited to the mouse-adapted African MR766 strain or infection at early gestation. Here, we compared infection of Asian and African strains in the fetal pig model at midgestation. Both strains caused fetal infection. ZIKV was detected in placenta, amniotic membrane, amniotic fluid, fetal blood, and brain. The African strain produced more vigorous in utero infection as represented by more efficient virus transmission between siblings, and higher viral loads in fetal organs and membranes. Infection with both strains was associated with reduced fetal brain weight and increased number of placental CD163-positive cells, as well as elevated in utero interferon al

SUBMITTER: Udenze D 

PROVIDER: S-EPMC6711198 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature