Early increase of specialized pro-resolving lipid mediators in patients with ST-elevation myocardial infarction.

ABSTRACT:

Background

Termination of acute inflammation is an active process orchestrated by lipid mediators (LM) derived from polyunsaturated fatty acids, referred to as specialized pro-resolving mediators (SPM). These mediators also provide novel therapeutic opportunities for treating inflammatory disease. However, the regulation of these molecules following acute myocardial infarction (MI) remains of interest.

Methods

In this prospective observational study we aimed to profile plasma levels of SPMs in ST-elevation MI (STEMI) patients during the first week following MI. Plasma LM concentrations were measured in patients with STEMI (n = 15) at three time points and compared with stable coronary artery disease (CAD; n = 10) and healthy controls (n = 10).

Findings

Our main findin

SUBMITTER: Fosshaug LE 

PROVIDER: S-EPMC6711324 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature