Apathy Is Related to Cognitive Control and Striatum Volumes in Prodromal Huntington's Disease.

ABSTRACT:

Objectives

Apathy is a debilitating symptom of Huntington's disease (HD) and manifests before motor diagnosis, making it an excellent therapeutic target in the preclinical phase of Huntington's disease (prHD). HD is a neurological genetic disorder characterized by cognitive and motor impairment, and psychiatric abnormalities. Apathy is not well characterized within the prHD. In previous literature, damage to the caudate and putamen has been correlated with increased apathy in other neurodegenerative and movement disorders. The objective of this study was to determine whether apathy severity in individuals with prHD is related to striatum volumes and cognitive control. We hypothesized that, within prHD individuals, striatum volumes and cognitive control scores would be related to ap

SUBMITTER: Misiura MB 

PROVIDER: S-EPMC6711382 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature