Muscle radiodensity loss during cancer therapy is predictive for poor survival in advanced endometrial cancer.

ABSTRACT:

Background

Treatment-related toxicities and decreased levels of patient performance during cancer therapy might contribute to body composition changes and thereby impact outcomes. However, the effect of longitudinal body composition changes on outcomes in patients with advanced endometrial cancer is unknown. This study investigated the association between body composition changes during staging surgery and adjuvant chemoradiotherapy and outcomes in patients with stage III endometrial cancer.

Methods

Pretreatment and post-treatment computed tomography (CT) images of 131 patients with stage III endometrial cancer who were treated between 2008 and 2016 were analysed. All CT images were contrast enhanced and acquired according to the standardized protocol. The skeletal muscle in

SUBMITTER: Lee J 

PROVIDER: S-EPMC6711455 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature