Mometasone or Tiotropium in Mild Asthma with a Low Sputum Eosinophil Level.

ABSTRACT:

Background

In many patients with mild, persistent asthma, the percentage of eosinophils in sputum is less than 2% (low eosinophil level). The appropriate treatment for these patients is unknown.

Methods

In this 42-week, double-blind, crossover trial, we assigned 295 patients who were at least 12 years of age and who had mild, persistent asthma to receive mometasone (an inhaled glucocorticoid), tiotropium (a long-acting muscarinic antagonist), or placebo. The patients were categorized according to the sputum eosinophil level (<2% or ≥2%). The primary outcome was the response to mometasone as compared with placebo and to tiotropium as compared with placebo among patients with a low sputum eosinophil level who had a prespecified differential response to one of the trial agents.

SUBMITTER: Lazarus SC 

PROVIDER: S-EPMC6711475 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature