A single-nucleotide polymorphism influences brain morphology in drug-naive patients with major depressive disorder.

ABSTRACT:

Objective

Recently, a genome-wide association study successfully identified genetic variants associated with major depressive disorder (MDD). The study identified 17 independent single-nucleotide polymorphisms (SNPs) significantly associated with diagnosis of MDD. These SNPs were predicted to be enriched in genes that are expressed in the central nervous system and function in transcriptional regulation associated with neurodevelopment. The study aimed to investigate associations between 17 SNPs and brain morphometry using magnetic resonance imaging (MRI) in drug-naïve patients with MDD and healthy controls (HCs).

Methods

Forty-seven patients with MDD and 42 HCs were included. All participants underwent T1-weighted structural MRI and genotyping. The genotype-diagnosis intera

SUBMITTER: Katsuki A 

PROVIDER: S-EPMC6711561 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature