A high-fat diet impacts memory and gene expression of the head in mated female Drosophila melanogaster.

ABSTRACT: Obesity predisposes humans to a range of life-threatening comorbidities, including type 2 diabetes and cardiovascular disease. Obesity also aggravates neural pathologies, such as Alzheimer's disease, but this class of comorbidity is less understood. When Drosophila melanogaster (flies) are exposed to high-fat diet (HFD) by supplementing a standard medium with coconut oil, they adopt an obese phenotype of decreased lifespan, increased triglyceride storage, and hindered climbing ability. The latter development has been previously regarded as a potential indicator of neurological decline in fly models of neurodegenerative disease. Our objective was to establish the obesity phenotype in Drosophila and identify a potential correlation, if any, between obesity and neurological decline through be

SUBMITTER: Rivera O 

PROVIDER: S-EPMC6711602 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature