<i>SDHD</i> Promoter Mutations Ablate GABP Transcription Factor Binding in Melanoma.

ABSTRACT: SDHD encodes subunit D of the succinate dehydrogenase complex, an integral membrane protein. Across cancer types, recurrent SDHD promoter mutations were reported to occur exclusively in melanomas, at a frequency of 4% to 5%. These mutations are predicted to disrupt consensus ETS transcription factor-binding sites and are correlated with both reduced SDHD gene expression and poor prognosis. However, the consequence of these mutations on SDHD expression in melanoma is still unclear. Here, we found that expression of SDHD in melanoma correlated with the expression of multiple ETS transcription factors, particularly in SDHD promoter wild-type samples. Consistent with the predicted loss of ETS transcription factor binding, we observed that recurrent hot

SUBMITTER: Zhang T 

PROVIDER: S-EPMC6711603 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature