Phosphodiesterase 10A IgG: A novel biomarker of paraneoplastic neurologic autoimmunity.

ABSTRACT:

Objective

To describe a novel antibody biomarker of neurologic paraneoplastic autoimmunity specific for phosphodiesterase 10A (PDE10A), a striatum-enriched phosphodiesterase, and to characterize the clinical phenotype of patients with PDE10A immunoglobulin G (IgG).

Methods

We describe 7 patients with autoantibodies specific for PDE10A identified in the Mayo Clinic Neuroimmunology Laboratory. Patient specimens (sera, 7; CSF, 4) produced identical basal ganglia-predominant synaptic staining of murine brain tissue by indirect immunofluorescence. The autoantigen was identified by immunoprecipitation and mass spectrometry as PDE10A, and confirmed by antigen-specific recombinant Western blot and cell-based assays, and immune absorption experiments.

Results

The median patien

SUBMITTER: Zekeridou A 

PROVIDER: S-EPMC6711657 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature