Measures of obesity are associated with MRI markers of brain aging: The Northern Manhattan Study.

ABSTRACT:

Objective

To examine associations between measures of obesity in middle to early-old age with later-life MRI markers of brain aging.

Methods

We analyzed data from the Northern Manhattan MRI Sub-Study (n = 1,289). Our exposures of interest were body mass index (BMI), waist circumference (WC), waist-to-hip ratio, and plasma adiponectin levels. Our outcomes of interest were total cerebral volume (TCV), cortical thickness, white matter hyperintensity volume (WMHV), and subclinical brain infarcts (SBI). Using multivariable linear and logistic regression models adjusted for sociodemographics, health behaviors, and vascular risk factors, we estimated β coefficients (or odds ratios) and 95% confidence intervals (CIs) and tested interactions with age, sex, and race/ethnicity.

Resu

SUBMITTER: Caunca MR 

PROVIDER: S-EPMC6711659 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature