Mechanisms underlying sharpening of visual response dynamics with familiarity.

ABSTRACT: Experience-dependent modifications of synaptic connections are thought to change patterns of network activities and stimulus tuning with learning. However, only a few studies explored how synaptic plasticity shapes the response dynamics of cortical circuits. Here, we investigated the mechanism underlying sharpening of both stimulus selectivity and response dynamics with familiarity observed in monkey inferotemporal cortex. Broadening the distribution of activities and stronger oscillations in the response dynamics after learning provide evidence for synaptic plasticity in recurrent connections modifying the strength of positive feedback. Its interplay with slow negative feedback via firing rate adaptation is critical in sharpening response dynamics. Analysis of changes in temporal patterns

SUBMITTER: Lim S 

PROVIDER: S-EPMC6711664 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature