²⁸Si total body irradiation injures bone marrow hematopoietic stem cells via induction of cellular apoptosis.

ABSTRACT: Long-term space mission exposes astronauts to a radiation environment with potential health hazards. High-energy charged particles (HZE), including ²⁸Si nuclei in space, have deleterious effects on cells due to their characteristics with high linear energy transfer and dense ionization. The influence of ²⁸Si ions contributes more than 10% to the radiation dose equivalent in the space environment. Understanding the biological effects of ²⁸Si irradiation is important to assess the potential health hazards of long-term space missions. The hematopoietic system is highly sensitive to radiation injury and bone marrow (BM) suppression is the primary life-threatening injuries after exposure to a moderate dose of radiation. Therefore, in the present study we investi

SUBMITTER: Chang J 

PROVIDER: S-EPMC6711775 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature