Complex polypharmacy in bipolar disorder: Side effect burden, adherence, and response predictors.

ABSTRACT:

Background

Complex polypharmacy (CP) is common in bipolar disorder (BD). We assessed the associations between CP, adherence, and side effect burden, and patient traits associated with clinical improvement in relationship to CP.

Methods

We conducted a secondary analysis of 482 adult BD participants in the Bipolar CHOICE trial. We examined the associations between CP (use of ≥3 BD medications) and non-adherence (missing >30% of BD medication doses in the last 30 days) and side effect burden (Frequency, Intensity and Burden of Side Effects Rating scale) using multivariate models with patient random effects. We used logistic regression to assess the patient traits associated with remission among those with majority CP use (Clinical Global Impression-Severity for BD score ≤2 for

SUBMITTER: Fung VC 

PROVIDER: S-EPMC6711795 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature