Biomarkers improve prediction of 30-day unplanned readmission or mortality after paediatric congenital heart surgery.

ABSTRACT:

Objective

To evaluate the association between novel pre- and post-operative biomarker levels and 30-day unplanned readmission or mortality after paediatric congenital heart surgery.

Methods

Children aged 18 years or younger undergoing congenital heart surgery (n = 162) at Johns Hopkins Hospital from 2010 to 2014 were enrolled in the prospective cohort. Collected novel pre- and post-operative biomarkers include soluble suppression of tumorgenicity 2, galectin-3, N-terminal prohormone of brain natriuretic peptide, and glial fibrillary acidic protein. A model based on clinical variables from the Society of Thoracic Surgery database was developed and evaluated against two augmented models.

Results

Unplanned readmission or mortality within 30 days of cardiac surgery occurr

SUBMITTER: Brown JR 

PROVIDER: S-EPMC6711799 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature