Hepatectomy promotes recurrence of liver cancer by enhancing IL-11-STAT3 signaling.

ABSTRACT:

Background

Patients undergoing surgical resection of hepatocellular carcinoma (HCC) are at risk of recurrence; however, the underlying mechanism remains poorly understood.

Methods

Through the analysis of gene expression profiles in tumour and matched normal tissues from patients with hepatocellular carcinoma (HCC), we identified differences in interleukin-11 (IL-11) expression. Further, we used genetic mouse, orthotopic tumour, chemically induced, and orthotopic allograft models to study the correlation between IL-11 and postsurgical recurrence. Additionally, we conducted a series of experiments, including histology and immunohistochemistry analysis, three-dimensional culture, immunofluorescence, western blotting, enzyme-linked immunosorbent assay (ELISA) and flow cytometry

SUBMITTER: Wang D 

PROVIDER: S-EPMC6711863 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature