Functional roles of ST8SIA3-mediated sialylation of striatal dopamine D₂ and adenosine A_2A receptors.

ABSTRACT: Sialic acids are typically added to the end of glycoconjugates by sialyltransferases. Among the six ST8 α-N-acetyl-neuraminide α-2,8-sialyltransferases (ST8SIA) existing in adult brains, ST8SIA2 is a schizophrenia-associated gene. However, the in vivo substrates and physiological functions of most sialyltransferases are currently unknown. The ST8SIA3 is enriched in the striatum. Here, we showed that ablation of St8sia3 in mice (St8sia3-KO) led to fewer disialylated and trisialylated terminal glycotopes in the striatum of St8sia3-KO mice. Moreover, the apparent sizes of several striatum-enriched G-protein-coupled receptors (GPCRs) (including the adenosine A_2A receptor (A_2AR) and dopamine D₁/D₂ receptors (D₁R and D₂R)) were sm

SUBMITTER: Lin CY 

PROVIDER: S-EPMC6712005 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature