Pressure accelerates the circadian clock of cyanobacteria.

ABSTRACT: Although organisms are exposed to various pressure and temperature conditions, information remains limited on how pressure affects biological rhythms. This study investigated how hydrostatic pressure affects the circadian clock (KaiA, KaiB, and KaiC) of cyanobacteria. While the circadian rhythm is inherently robust to temperature change, KaiC phosphorylation cycles that were accelerated from 22 h at 1 bar to 14 h at 200 bars caused the circadian-period length to decline. This decline was caused by the pressure-induced enhancement of KaiC ATPase activity and allosteric effects. Because ATPase activity was elevated in the CI and CII domains of KaiC, while ATP hydrolysis had negative activation volumes (ΔV^≠), both domains played key roles in determining the period length of the Kai

SUBMITTER: Kitahara R 

PROVIDER: S-EPMC6712028 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature