SerpinB2 inhibits migration and promotes a resolution phase signature in large peritoneal macrophages.

ABSTRACT: SerpinB2 (plasminogen activator inhibitor type 2) has been called the "undecided serpin" with no clear consensus on its physiological role, although it is well described as an inhibitor of urokinase plasminogen activator (uPA). In macrophages, pro-inflammatory stimuli usually induce SerpinB2; however, expression is constitutive in Gata6+ large peritoneal macrophages (LPM). Interrogation of expression data from human macrophages treated with a range of stimuli using a new bioinformatics tool, CEMiTool, suggested that SerpinB2 is most tightly co- and counter-regulated with genes associated with cell movement. Using LPM from SerpinB2^-/- and SerpinB2^R380A (active site mutant) mice, we show that migration on Matrigel was faster than for their wild-type controls. Confocal m

SUBMITTER: Schroder WA 

PROVIDER: S-EPMC6712035 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature