MicroRNA let-7-TGFBR3 signalling regulates cardiomyocyte apoptosis after infarction.

ABSTRACT:

Background

Myocardial infarction (MI) is a life-threatening disease, often leading to heart failure. Defining therapeutic targets at an early time point is important to prevent heart failure.

Methods

MicroRNA screening was performed at early time points after MI using paired samples isolated from the infarcted and remote myocardium of pigs. We also examined the microRNA expression in plasma of MI patients and pigs. For mechanistic studies, AAV9-mediated microRNA knockdown and overexpression were administrated in mice undergoing MI.

Findings

MicroRNAs let-7a and let-7f were significantly downregulated in the infarct area within 24 h post-MI in pigs. We also observed a reduction of let-7a and let-7f in plasma of MI patients and pigs. Inhibition of let-7 exacerbated card

SUBMITTER: Chen CY 

PROVIDER: S-EPMC6712055 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature